Peptide microarrays coupled to machine learning reveal individual epitopes from human antibody responses with neutralizing capabilities against SARS-CoV-2기계 학습과 결합된 펩티드 마이크로어레이는 SARS-CoV-2에 대한 중화 기능을 가진 인간 항체 반응의 개별 에피토프를 나타냅니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, [키워드] anti-SARS-CoV-2 antibody Antibody binding assays binding epitope capture causative agent cellular coronavirus coronavirus SARS-CoV-2 Course COVID-19 detectable epitope Epitopes human antibody response IgA IgG IgM antibody immunoassays incubated infected with SARS-CoV-2 machine learning Microarray N-terminus negative control samples neutralization neutralization assays Neutralizing Neutralizing antibodies nine overlapping Patient peptide peptide arrays peptides positive protective effect Protective effects random Random forest response S protein SARS CoV SARS CoV-2 SARS-CoV-2 sera serology Serology. Specific structural protein structural proteins the disease the S protein vaccine candidate vaccine candidates Viral [DOI] 10.1080/22221751.2022.2057874 PMC 바로가기 [Article Type] Article
The humoral response and antibodies against SARS-CoV-2 infection Reviews Published on 2022-06-272022-10-05 Journal: Nature Immunology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] antibody COVID-19 pandemic feature human antibody response humoral humoral immune response Infection Neutralizing antibodies observation people with COVID-19 Protective review SARS-COV-2 infection SARS-CoV-2 virus the SARS-CoV-2 virus Vaccine design variant [DOI] 10.1038/s41590-022-01248-5 [Article Type] Reviews
An antibody targeting the N-terminal domain of SARS-CoV-2 disrupts the spike trimerSARS-CoV-2의 N-말단 도메인을 표적으로 하는 항체는 스파이크 삼량체를 파괴합니다Article Published on 2022-06-012022-09-12 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome Adaptive immunity antibody Antigen B cell binding Cell cell-to-cell spread Cluster coronavirus COVID-19 Culture disrupt dominant epitope functional Genetic human Angiotensin-converting enzyme human antibody response IGHV1-24 immunoglobulins immunology inhibited mice MOST N-terminal domain neutralizing antibody NTD Protective Protective antibody Protein provide receptor recognize representing S protein SARS-CoV-2 SARS-CoV-2-neutralizing antibody Sequencing single B cell specificity spike trimer the receptor-binding domain the S protein the SARS-CoV-2 trimer Trimers virion Virology Virology. virus [DOI] 10.1172/JCI159062 PMC 바로가기 [Article Type] Article
Sex Disparities and Neutralizing-Antibody Durability to SARS-CoV-2 Infection in Convalescent Individuals회복기 개인의 SARS-CoV-2 감염에 대한 성 격차 및 중화항체 내구성Research Article Published on 2021-08-252022-09-12 Journal: mSphere [Category] MERS, SARS, 진단, [키워드] age antibodies antibody Antibody titer association binding antibody cardiometabolic caused clinical parameter Clinical parameters Cohort collected Comorbidities Comorbidity convalescent coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19-convalescent individual COVID-19-convalescent individuals death discrepancy disparity Donor evaluated expand female functional functional antibody response functional antibody responses human antibody response immunology individual Infection longitudinal samples magnitude male Male sex morbidity and mortality Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody response neutralizing antibody responses Neutralizing antibody titer pandemic positive RBD reason reason for Receptor binding domain responses robust SARS-CoV-2 SARS-CoV-2 antigen sera serum antibodies Severe acute respiratory syndrome Severe acute respiratory syndrome-related coronavirus Sex significantly Support Symptom symptom onset [DOI] 10.1128/mSphere.00275-21 PMC 바로가기 [Article Type] Research Article
Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infectionmRNA-1273 백신 접종에 의해 유도된 항체는 SARS-CoV-2 감염에서보다 수용체 결합 도메인에 더 광범위하게 결합합니다Research Article Published on 2021-06-302022-09-10 Journal: Science Translational Medicine [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immunity affected antibodies antibody antibody epitope antibody epitopes antibody immunity Antibody Response Antibody responses antigenic evolution binding breadth characterized convalescent sera coronavirus deep demonstrated dose elicited epitope Epitopes erosion greater human antibody response Immunity immunization Infection less Moderna mRNA-1273 vaccine mRNA mRNA-1273 mRNA-1273 COVID-19 vaccine Mutation natural infection neutralization Neutralizing activity Neutralizing antibodies neutralizing antibody polyclonal antibodies polyclonal antibody raised RBD RBD mutation RBD-binding antibody Receptor binding domain Receptor-binding domain respiratory SARS-CoV-2 SARS-CoV-2 evolution SARS-COV-2 infection SARS-CoV-2 spike protein sera severe acute respiratory syndrome Coronavirus specificity Spike protein susceptibility the antibody response the RBD the receptor-binding domain the SARS-CoV-2 vaccination Vaccine variant variants Viral viral evolution viral mutation Viral mutations [DOI] 10.1126/scitranslmed.abi9915 PMC 바로가기 [Article Type] Research Article
Dynamics of antibodies to SARS‐CoV‐2 in convalescent plasma donorsOriginal Article Published on 2021-05-162022-10-31 Journal: Clinical & Translational Immunology [Category] COVID-19, [키워드] ACE2‐competitive ELISA Adults analysed Analysis antibodies antibody Antibody Response Concentration convalescent convalescent plasma correlated COVID‐19 declined Donor Dynamics human antibody response IgG IgG antibody IgG level IgG response Immunoglobulin Immunological memory individual individuals longitudinal magnitude median memory neutralisation nucleocapsid protein objective occur onset of symptoms profile profiles Quantitative analysis RBD receptor‐binding domain reduction Result SARS‐CoV‐2 SARS‐CoV‐2 infection seropositive Spike protein subjects symptom onset Treatment Variation [DOI] 10.1002/cti2.1285 PMC 바로가기 [Article Type] Original Article
The antigenic anatomy of SARS-CoV-2 receptor binding domainSARS-CoV-2 수용체 결합 도메인의 항원 해부학Article Published on 2021-04-152022-09-12 Journal: Cell [Category] MERS, SARS, 진단, [키워드] Abstract ACE2 blockers Anatomy animal models antibody antibody binding site antigenic bind binding binding domain binding mode complex coronavirus, SARS-CoV-2, anti-RBD antibody, receptor binding domain, antibody, immune responses, virus structure data-driven dissect Emergency use epitope example Fab glycosylated human antibody response Human monoclonal antibody identify immune protection inhibitory inhibitory antibody Interaction mAb mAbs Map mapped Microscopy MOST N-terminal domain neutralize Neutralizing neutralizing antibody NTD panel of antibody prophylactically PROTECT Protein RBD RBD binding receptor Receptor binding domain recognizing Recovered COVID-19 patients SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor structures the RBD unique Virus spike X-ray crystallography [DOI] 10.1016/j.cell.2021.02.032 PMC 바로가기 [Article Type] Article
Distinct antibody repertoires against endemic human coronaviruses in children and adultsResearch Article Published on 2021-02-222022-10-30 Journal: JCI Insight [Category] COVID-19, MERS, [키워드] Acidic Acute respiratory infection antibody antibody repertoire Antibody Response B cell epitopes B cell response children Cohort comprehensive analysis conserved Coronavirus infection Coronaviruses cross-reactive dominant donors endemic HCoV endemic human coronavirus Epidemic fusion peptide HCoV-HKU1 human antibody response humans IgG immunoglobulins immunology immunoprecipitation Infectious disease linear monoclonal antibody N-terminal nucleocapsid peptide polyprotein predominant Prophylactic Proteins ranged Region S2′ cleavage Sequencing Seroprevalence specificity the spike protein therapeutic Vaccine design virus [DOI] 10.1172/jci.insight.144499 PMC 바로가기 [Article Type] Research Article
A 10-Minute “Mix and Read” Antibody Assay for SARS-CoV-2SARS-CoV-2에 대한 10분 "혼합 및 판독" 항체 분석Article Published on 2021-01-202022-09-01 Journal: Viruses [Category] 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antibody detection antibody tests Antigen applicability approach coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 described detectable diagnostic ELISA ELISAs energy transfer enzyme evaluated fluorophore help homogenous human antibody response immunoassay Immunoglobulin immunoglobulins immunosorbent individual individuals with COVID-19 Infection initial management Microneutralization test MNT negative controls Neutralizing antibody response nucleocapsid protein pandemic Patient Protein respiratory resulting SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 SP sensitivity serodiagnosis serology serum/plasma severe acute respiratory syndrome Coronavirus specificity spike glycoprotein target TR-FRET vaccine responses [DOI] 10.3390/v13020143 PMC 바로가기 [Article Type] Article
Multiplexed detection and quantification of human antibody response to COVID-19 infection using a plasmon enhanced biosensor platformResearch article Published on 2021-01-012022-10-05 Journal: Biosensors & bioelectronics [Category] SARS, 치료기술, [키워드] antibody Antibody binding Antigen approach binding interaction biosensor Blood correlated COVID-19 COVID-19 antibody tests COVID-19 infection diagnosing diagnostic tests Dilution Efficacy ELISA enzyme evaluated fluorescent human antibody response IgA IgG IgM immunoassay Immunoglobulin immunosorbent interactions isotypes Last linear measure microsphere multiplex nucleocapsid protein pandemic Patient plasmonic platform quantification Quantitative SARS CoV-2 sensitivity serum serum IgG serum sample target test result was used yielding [DOI] 10.1016/j.bios.2020.112679 [Article Type] Research article